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Wieslab provides new tests within neuroimmunology

March 31, 2015 - Company News, Product News, Disease Area News
As an addition to our broad test menu of autoimmune diseases and neurological markers Wieslab now offers the following new tests:

Suspected autoimmune encephalitis and / or autoimmune cerebellar ataxia

New antibodies associated with autoimmune encephalitis and in some cases cerebellar ataxia have been identified against the proteins DPPX1, HOMER32, IgLON53 and ITPR14.

Suspected paraneoplastic cerebellar degeneration associated with malignant melanoma

The presence of autoantibodies against CARP VIII5,6 have been reported in patients with paraneoplastic cerebellar degeneration (PCD) associated with malignant melanoma.

The tests can be ordered separately or as a part of the test panel: Extended analysis of neuronal antibodies (paraneoplastic syndromes and limbic encephalitis) (Link to the request form).

Suspicion of sporadic Creutzfeldt-Jakob disease

In addition to various forms of Creutzfeldt-Jakob disease, elevated levels of 14-3-37,8,9 in cerebrospinal fluid can also be found in rapidly progressive dementia and numerous other conditions that are associated with significant and rapid degradation of neuronal tissue.

This neuronal marker protein analysis can only be ordered separately (Link to request form).

Please also visit our new website for pediatric autoimmune neuropsychiatric syndrome - www.pandas-pans.com

Please send an email to diagnostic.services@wieslab.com if you have questions.

Anna Laurén
Wieslab Laboratory Manager
+46 702 74 34 82, anna.lauren@wieslab.com
(Tests and test results)

Michael Benjamin Akoh
Vice President Wieslab
+46 702 62 37 15, mia@wieslab.com
(Service offering and pricing)

 

References

1 Boronat A, et al. Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels. Ann Neurol 73 (2013) 120-128 and Lancaster E, et al. Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology 77 (2011) 179-189 and

 Frank Leypoldt, et.al.  “Autoimmune encephalopathies” Ann. N.Y. Acad. Sci. (2014) 1–21. 

2 Höftberger R et.al. Patient with homer-3 antibodies and cerebellitis, JAMA Neurol. 2013 Apr; 70(4):506-9.

3 Sabater L et.al. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterization of the antigen, and post-mortem study. Lancet Neurol. 2014 Jun; 13(6):575-86 and Leypoldt F, et al Autoimmune encephalopathies. Ann N Y Acad Sci. 2014 Oct 14.

4 Sven Jarius, et.al. Antibodies to the inositol 1, 4, 5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia, Journal of Neuroinflammation, 2014, 11:206.

5 Bataller L, et.al. Carbonic anhydrase-related protein VIII: autoantigen in paraneoplastic cerebellar degeneration, Ann Neurol. 2004 Oct; 56(4):575-9.

6 Höftberger R, et.al. Carbonic anhydrase-related protein VIII antibodies and paraneoplastic cerebellar degeneration, Neuropathol Appl Neurobiol. 2014 Aug; 40(5):650-3.

7 Muayqil T1, Gronseth G, Camicioli R. Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology. Neurology. 2012 Oct 2; 79(14):1499-506

8 Coulthart MB et.al. Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year prospective study. BMC Neurol. 2011 Oct 27; 11:133.

9 Hamlin C et.al. A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease. Neurology. 2012 Aug 7;79(6):547-52

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