Cardiolipin antibodies – IgG and IgM

Indication

Suspected autoimmune arterial and / or venous thrombosis, thrombocytopenia, and repeated abortions. This is seen in primary antiphospholipid syndrome (APS) and systemic lupus erythematous with secondary anti-phospholipid syndrome (APS).

Method

The analysis is performed by ELISA. Answers are given both in IgG and IgM antibodies.

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Answer

The result is given as negative, borderline or positive with a value.

Interpretation

Elevated levels of IgG and/or IgM antibodies against cardiolipin at two sampling intervals of at least 12 weeks apart are markers of anti-phospholipid syndrome (APS). The syndrome is often associated with SLE (secondary APS), but also occurs without evidence of inflammatory systemic disease (primary APS). Antibodies to cardiolipin can also be seen transiently in connection with infection without relation to thrombosis.

If suspicion of antiphospholipid syndrome (APS) remains despite negative results regarding the classical antiphospholipid associated antibodies (lupus anticoagulant (LA), IgG- and/or IgM-antibodies against beta2-Glycoprotein-1 and cardiolipin), IgA-antibodies against cardiolipin/ beta2-Glycoprotein-1 support the APS-diagnosis in isolated cases. In addition, antibodies against phosphatidylserine can be of value.

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Packages and other tests

View other packages Antiphospholipid syndrome (APS) (510), Drug induced lupus (541), Systemic lupus erythematosus (SLE) (541). View other tests Beta-2 Glycoprotein-1 antibodies - IgG and IgM

Acute test