Desmoglein 1 and 3 IgG antibodies

Indication

Suspicion of autoimmune skin disease, e.g. pemphigus and differential diagnosis of pemphigoid, EBA etc.

Method

ELISA with recombinant antigens desmoglein 1 and 3. Desmoglein 1 is a desmosomal cadherin with a molecular weight of 160kD, whereas desmoglein 3 has a molecular weight of 130kD.

Answer

The result is given as positive or negative.

Reference range

< 1.00 negative and ≥ 1.00 positive.

Interpretation

Pemphigus is a group of life threatening autoimmune bullous diseases that present with intraepithelial blisters. The molecular background of the blistering is that the adhesion between keratinocytes is disturbed (acantholysis) by the autoantibodies against intercellular adhesive structures. In pemphigus foliaceus the antibodies are mainly directed against desmoglein 1. In pemphigus vulgaris the antibodies are mainly directed against the extracellular domain of desmoglein 3 but some patients may also have antibodies against desmoglein 1.

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Packages and other tests

View other packages Pemphigus/Pemphigoid (Bullous dermatosis) (550)

20 years experience