dsDNA antibodies


Suspicion of systemic lupus erythematosus or incipient exacerbation of this disease, chronic aggressive hepatitis of the “lupoid hepatitis” (autoimmune hepatitis) type.


IIF with the flagellate Crithidia luciliae as a substrate on a slide.

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The result is given as negative, weak, medium or strong positive after evaluation of the intensity of the immunofluorescence. A positive result is followed by a titer.


Analysis of antibodies against double stranded DNA (dsDNA) is performed in further investigation of positive IF-ANA, suspicion of systemic lupus erythematosus or onset of exacerbation of this disease. IgG antibodies against dsDNA is a strong marker for systemic lupus erythematosus (SLE) and is associated with SLE-nephritis but can also be seen in autoimmune hepatitis type 1.

Positive findings of these antibodies (detected by IF microscopy) have high diagnostic specificity for systemic lupus erythematosus (90%). Over time, up to 70% of patients with systemic lupus erythematosus have some time during the disease progression IgG anti-dsDNA. A rapid increase in the level of anti-dsDNA often indicates an impairment of the disease. During remission, the values may become normal.

Weak positive findings with a screening method that cannot be verified by Crithidia tests can be seen in other chronic inflammatory rheumatic diseases and are usually of low clinical value.

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Packages and other tests

View other packages ANCA for Systemic Vasculitis/anti-GBM Goodpastures syndrome (501), Glomerulonephritis (500)

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