Fibrillarin antibodies

Indication

Suspicion of scleroderma, differential diagnosis for Raynaud’s phenomenon.

Method

Phadia ELIA

Answer

The result is expressed as negative, borderline or positive with a value. 

Interpretation

Fibrillarin antibodies occur in about 4% of patients with systemic scleroderma, often together with antibodies against centromeres, RNA-polymerase and Scl-70. It has also been described in SLE and primary Raynaud’s phenomenon. Anti-fibrillarin is more common in patients of African descent than Caucasians. Anti-fibrillarin is more specific for the diffuse form of scleroderma than the limited one.

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Packages and other tests

View other packages Scleroderma-Expanded analysis (527). View other tests ANA screen (HEp-2 cells)

Clinical studies