IgG subclasses of anti-GBM

Indication

Follow-up analysis of Goodpasture’s syndrome and Wegener’s granulomatosis and other reno-pulmonary syndromes. May indicate patients who should be monitored very closely and may predict relapses.

Method

ELISA with specific GP antigen and subclass specific monoclonal antibodies.

Answer

The result is given as arbitrary units per ml.

Interpretation

The most common subclasses of these diseases are IgG1 and IgG4. IgG2 and IgG3 occur in low quantities. An unusual subclass distribution can indicate a different clinical course. Changes in the subclass distribution can be used to study relapses in the disease.

Read more about sampling

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