Jo-1 antibodies

Indication

Jo-1 is included in the analysis ENA screen. See ENA for indication, method, answer and reference range.

Interpretation

Positive in 25% of patients with polymyositis/dermatomyositis and almost pathognomonic for the disease. Antibodies against Jo-1 are directed against histidyl-tRNA synthetase. Other anti-synthetase antibodies include the antigens OJ, EJ, PL-7, PL-12, KS and Zo. Patients with other anti-tRNA-synthetase antibodies manifest symptoms much the same as those with anti-Jo-1.

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20 years experience