nRNP (U1-RNP and snRNP) antibodies

Indication

nRNP-antibodies are included in the analysis ENA screen. See ENA screen for indication, method, answer and reference range.

Interpretation

Occur in almost all patients with MCTD, in 5-50% of patients with SLE and is most common in patients with lung manifestations or signs of myositis, Raynaud’s phenomenon and positive RF-IgM. Antibodies may also occur in RA and polymyositis/ dermatomyositis and scleroderma. A few healthy people, as well as people with malaria, bilharzia and leishmaniasis, may have antibodies against nRNP.

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