Steroid 21 hydroxylase (S21HY) antibodies

Indication

Suspicion of Addison’s disease.

Method

Radioimmunoprecipitation with a recombinant antigen.

Answer

The result is given as a ratio between patient serum and normal serum.

Interpretation

Steroid 21-hydroxylase is the principal antigen in autoimmune adrenal cortex insufficiency (Addison’s disease). The antibody has been observed in 93% of patients with the diagnosis of Addison’s disease.

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