Streptolysin O antibodies

Indication

Suspicion of glomerulonephritis.

Method

Agglutination

Answer

The result is given as negative or positive with a value (IU/mL).

Interpretation

Detection of antibodies against streptococci can give a retrospective diagnosis of infections, caused by beta-haemolytic streptococci group A, when there is a suspicion of complications, e.g. rheumatic fever, acute post-streptococcal glomerulonephritis or erythema nodosum. The antibody levels begin to rise about a week after infection with beta-haemolytic streptococci group A and reach their highest value after 3-5 weeks. Two samples at an interval of at least 4 weeks are recommended to determine the seroconversion. Positive antistreptolysin-O is observed in 80% of patients with rheumatic fever or acute post-streptococcal glomerulo-nephritis (APGN).

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Packages and other tests

View other packages Glomerulonephritis (500). View other tests ANA screen (HEp-2 cells), dsDNA antibodies, GBM antibodies (the Goodpasture antigen), MPO-ANCA (capture technique), MPO-ANCA (direct technique), Phospholipase A2 receptor (PLA2R) antibodies, PR3-ANCA (capture technique), PR3-ANCA (direct technique), Thrombospondin Type 1 Domain Containing 7A (THSD7A) antibodies

Clinical studies