Aquaporin 4 antibodies (NMO)

Indication

Suspected Neuromyelitis Optica (NMO).

Method

Indirect immunofluorescens (IIF) in cells transfected with Aquaporin 4 (AQP4).

Answer

Results are given as positive or negative. A positive result is followed by a titre.

Interpretation

Antibodies against AQP4 in serum are a strong marker for neuromyelitis optica (NMO/NMOSD) and can be detected in about 75-80% of the cases.

It is recommended to use the test on serum. However, seronegative cases where anti-AQP4 antibodies have been detected in the cerebrospinal fluid (CSF) have been reported. According to guidelines the relevance of anti-AQP4 antibodies in CSF is unclear and the diagnostic criteria are based on analysis on serum.

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Packages and other tests

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