Glycine receptor (GlyR) antibodies


Suspected Stiff person syndrome and especially PERM (Progressive encephalomyelitis with rigidity and myoclonus).


The assay is performed by indirect immuno fluorescence (IIF).


The answer is given as titer. 


The analysis establishes if the patient sample contains autoantibodies against the glycine receptor (GlyR). Publications show that in most cases the antibodies bind to the glycine receptor alpha 1 (GlyRalfa 1). These antibodies are particularly associated with PERM (Progressive encephalomyelitis with rigidity and myoclonus) and Stiff person syndrome. In less than 10% of the cases, the anti-GlyR positive patients showed a correlation with paraneoplastic cancers.

The antigen is a sub unit to pentameric inhibitory glycine receptor. This receptor mediates postsynaptic inhibition of the central nervous system.

Generally, treatment with immunotherapy is more effective against auto-antibodies directed to extracellular antigen than with auto-antibodies against intracellular antigens.

Read more about sampling


PMID: 15342008: 15258215: 21747075: 22448032; PMCID: Alpha


Packages and other tests

View other packages Paraneoplastic Syndromes and Limbic Encephalitis (560, 561 and 562), Stiff person syndrome/PERM (568). View other tests Amphiphysin antibodies, GAD antibodies

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