VGCC (voltage-gated calcium channel) antibodies


Suspicion of paraneoplastic neuropathy, Lambert-Eaton myasthenic syndrome and cerebellar dysfunction.


Radioimmunoprecipitation (RIA).


The answer given as a ratio for VGCC N-type antibodies)

The answer is given as pmol / L for P/Q type antibodies.


Calcium channel antibodies occur in paraneoplastic neuropathy in e.g. small cell lung cancer, but even without this association. Causes include Lambert-Eaton myasthenic syndrome and cerebellar dysfunction. It is primarily the VGCC P/Q type antibodies that are of clinical significance while the importance of VGCC N-type antibodies is less known.

Generally, treatment with immunotherapy is more effective against auto-antibodies directed to extracellular antigens than with auto-antibodies against intracellular antigens.

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PMID: 15342008: 15258215: 21747075: 22448032

Packages and other tests

View other packages Lambert-Eatons myastena syndrom (LEMS) (563), Paraneoplastic Syndromes and Limbic Encephalitis (560, 561 and 562). View other tests VGKC (voltage gated potassium channel) antibodies

Acute test