LGI-1 antibodies

Indication

Suspicion of paraneoplastic syndromes particularly in autoimmune encephalitis.

Method

Indirect immunofluorescence (IIF) using transfected cells.

Answer

The result is reported as positive or negative. A positive result is followed by a titer (serum).

Interpretation

LGI-1 is a subunit in the potassium channel complex (VGKC). Antibodies against LGI-1 have been reported in classical autoimmune encephalitis and epilepsy. Antibodies against LGI-1 are the second most common in autoimmune encephalitis following antibodies against NMDAR. Antibodies against LG-1 are detected more often in men, age when diagnosed has varied between 30-80 years (median 60 years). LGI-1 antibodies are associated with tumors (lung, thymoma but also other tumor forms) in 25-31% of the cases.

The LGI-1 belongs to the group of extracellular antigens. Generally, immunotherapy is more often effective in autoantibodies directed against extracellular antigens than in autoantibodies against intracellular antigens. Antibody titers can be used to monitor treatment effectiveness. Screening for cancer diagnosis is recommended.

Read more about sampling

References: 

PMID: 20663977: 15258215: 21747075: 22448032

Packages and other tests

View other packages Paraneoplastic Syndromes and Limbic Encephalitis (560, 561 and 562)

Clinical studies