Glial fibrillary protein (GFAP)

Reference range for different age ranges:

<2 years: <450 ng / L

2 years, <20 years: <175 ng / L

20 years, <60 years: <750 ng / L

> = 60 years: <1250 ng / L

Glial fibrillary protein (Glial fibrillary acidic protein, GFAP) is an intermediate filament protein expressed by most cells in the central nerve system and particularly astrocytes. With CNS damage as a result of trauma, disease, genetic mutations and chemical action astrocytes become reactive (called astrogliosis). Astrogliosis is characterized by increased synthesis of GFAP. GFAP levels are altered in many neurodegenerative diseases.

Results of GFAP levels should preferably examined together with other brain injury markers such as NFL, Tau, NSE, and optionally S-100 beta amyloid.

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Acute test