Phospho-tau

Indication

Alzheimer's disease, memory examination.

Reference range

Reference range for Phospho-Tau in CSF at different age intervals:

20 years - < 60 years: <60 ng/L
>=60 years: < 80 ng/L

Interpretation

Phospho-Tau (p-Tau) reflects the hyper phosphorylation of Tau and the formation of neurofibrillary. Tau can be phosphorylated to different degrees and p-Tau has a reduced ability to bind to microtubules, which means that the axons may be reduced stability. The specificity of increased Phospho-Tau is high for Alzheimer why you usually look normal p-Tau levels at other dementias.

Alzheimer's: Moderate to implemented powerful increased (sensitivity to detect Alzheimer's is 80%)
Acute stroke: Normal
CJD: Normal / slightly increased
Frontotemporal dementia: Normal
Lewy body dementia: Normal
Vascular dementia: Normal
ALS: Normal

Normal aging, MCI (Mild cognitive impairment) without progression to Alzheimer's, depression, Parkinson, non-acute cerebrovascular disease show normal levels of total Phospho-Tau.

Read more about sampling

Packages and other tests

. View other tests Beta-Amyloid, Tau

Clinical studies