Tau

Indication

Alzheimer's disease, memory examination, CNS parody injury.

Reference range

Reference range for Tau in CSF:  Normal level < 479 ng/L for individuals > 50 years

 

Interpretation

Total Tau reflects axonal decomposition. Tau occurs most in cortical omyelinated axon where they bind to microtubules with stabilizing effect. Tau can be phosphorylated to varying degrees (Phospho-Tau). Total Tau is used as a biomarker for Alzheimer's disease, but an increased level can also be seen in other degenerative central nervous system and stroke. The highest levels are seen in Creutzfeldt-Jakob's disease with rapidly progressive cortical degeneration.

Alzheimer's: Moderate to implemented powerful increased (sensitivity to detect Alzheimer's is 85%).  Acute stroke: Very sharply increased. CJD: Very sharply increased. Frontotemporal dementia: Normal / slightly increased. Lewy body dementia: Normal / slightly increased. Vascular dementia: Normal / slightly increased. ALS: Normal.

Normal aging, MCI (Mild cognitive impairment) without progression to Alzheimer's, depression, Parkinson, non-acute cerebrovascular disease show normal levels of total Tau.

Read more about sampling

Packages and other tests

View other packages CNS -Parenchymal damage (566). View other tests Beta-Amyloid 42, Phospho-tau

20 years experience