Alzheimer's disease, memory examination, CNS parody injury.

Reference range

Reference range for Tau in CSF: 
Normal level < 479 ng/L for individuals >50 years
Normal level < 360 ng/L for individuals 18-50 years
Normal level < 300 ng/L for individuals <18 years



Total Tau reflects axonal decomposition. Tau occurs most in cortical omyelinated axon where they bind to microtubules with stabilizing effect. Tau can be phosphorylated to varying degrees (Phospho-Tau). Total Tau is used as a biomarker for Alzheimer's disease, but an increased level can also be seen in other degenerative central nervous system and stroke. The highest levels are seen in Creutzfeldt-Jakob's disease with rapidly progressive cortical degeneration.

Alzheimer's: Moderate to implemented powerful increased (sensitivity to detect Alzheimer's is 85%).  Acute stroke: Very sharply increased. CJD: Very sharply increased. Frontotemporal dementia: Normal / slightly increased. Lewy body dementia: Normal / slightly increased. Vascular dementia: Normal / slightly increased. ALS: Normal.

Normal aging, MCI (Mild cognitive impairment) without progression to Alzheimer's, depression, Parkinson, non-acute cerebrovascular disease show normal levels of total Tau.

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Packages and other tests

View other packages CNS -Parenchymal damage (566). View other tests Beta-Amyloid 42, Phospho-tau

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