Trib2 antibodies

Indication

Suspicion of narcolepsy.

Method

Radioimmunoprecipitation

Response

The answer is given as negative or positive where a positive response is accompanied by a ratio.

Interpretation

Antibodies against Trib-2 have been detected in 12.5 to 26.1% of patients with narcolepsy with cataplexy. Trib-2 protein is expressed (amongst other) by hypecretin-1 secreting cells. There is a hypothesis that narcolepsy is induced due to an autoimmune response that destroys the hypocretin-1-producing cells. One of the studies has found autoantibodies in a greater degree in patients with a recent onset of narcolepsy and cataplexy symptoms and another study there has mainly been found autoantibodies in young patients. Trib-2 autoantibodies can also be detected in autoimmune uveitis but relevance is unknown. Over 90% of individuals with narcolepsy with cataplexy carry the genetic marker HLA-DQB1 * 0602. Hypocretin-1 levels are usually significantly reduced in individuals with narcolepsy.

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References

Cvetkovic-Lopes V, Bayer L, Dorsaz S, Maret S, Pradervand S, Dauvilliers Y, Lecendreux M, Lammers GJ, Donjacour CE, Du Pasquier RA, Pfister C, Petit B, Hor H, M√ľhlethaler M, Tafti M. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest. 2010 Mar; 120(3):713-9. PMID: 20160349

Kawashima M, Lin L, Tanaka S, Jennum P, Knudsen S, Nevsimalova S, Plazzi G, Mignot E. Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are Associated with Recent Onset of cataplexy. Sleep. 2010 Jul, 33 (7):869-74. PMID: 20614846

Toyoda H, Tanaka S, Miyagawa T, Honda Y, Tokunaga K, Honda M. Anti-Tribbles homolog 2 autoantibodies in Japanese patient with narcolepsy. Sleep. 2010 Jul, 33 (7):875-8. PMID: 20614847

Winding A, Ramelius A, Olsson T, Arnheim-Dahlstrom L, Lamb F, Khademi M, Ambati A, Maeurer M, Nilsson AL, Bomfim IL, Fink C, √Ö Lernmark H1N1 Antibodies and TRIB2 autoantibodies in narcolepsy patient Diagnosed in Conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010. J Autoimmun. 2014 May; 50:99-106. PMID: 24485154

Zhang Y, Davis JL, Li W. Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display. Mol Immunol. 2005 Jul; 42 (11) :1275-81. PMID: 15950723

Acute test