cN-1A (Mup44) Antibodies (IgG)

Indication

Sporadic inclusion body myositis (IBM)

Method

Semi-quantitative ELISA with cytosolic 5‚Äė-nucleotidase 1A (cN-1A) as antigen.

Interpretation

Anti-cN-1A (Mup44) is a serological biomarker for Sporadic Inclusion body myositis (IBM).

Studies show that antibodies against the protein cytoplasmic 5'nucleotidase (CN-1A) is very characteristic (95% specificity) for IBM, even if it cannot be demonstrated in all cases (sensitivity of about 30%).
The antibodies can also be detected in SLE, Sjögren's syndrome and other inflammatory muscle disorders, but then usually in low titers.

The disease is between 2-3 times as common in men as in women and occurs almost exclusively in people who are over 50 years.

References

Pluk H et al. Ann Neurol. 2013 (PMID: 23460448)
Hebert MK. et al. Ann Rheum Dis. 2016 (PMID: 25714931)
Hebert MK. et al. Curr. Opin. Rheumatol. 2015 (PMID: 26285103)
Larman HB. et al. Ann Neurol. 2013 (PMID 23596012)

Read more about sampling

Packages and other tests

View other packages Inflammatory Myopathies (Myositis) (551)

Clinical studies