mGluR5 antibodies

Indication

Suspicion of autoimmune encephalitis.

Method

Indirect immunofluorescence.

Response

Reported as positive (with titre) or negative.

Interpretation

Metabotropic glutamate receptors are transmembrane proteins in neuronal membranes. Unlike ionotropic receptors, metabotropic glutamate receptors (mGluRs) are not ion channels. Instead, they activate biochemical cascades, leading to the modification of other proteins, as for example ion channels.

Antibodies against mGluR5 (metabotropic glutamate receptor 5) have been reported in limbic encephalitis with (or without) Hodgkin's lymphoma (Ophelia syndrome). Recognition of this disorder is important since it can affect young individuals and is reversible.

It is recommended to use the test on serum. It has not been reported cases of only CSF positive.

Read more about sampling

Referenser

PMID: 24637228, 22013185, 24792345, 25081016

 

Acute test