Beta2-glykoprotein-1 antibodies – IgA


If suspicion of antiphospholipid syndrome (APS) remains despite negative results regarding the classical antiphospholipid associated antibodies (lupus anticoagulant (LA), IgG- and/or IgM-antibodies against beta2-Glycoprotein-1 and cardiolipin), IgA-antibodies against cardiolipin/ beta2-Glycoprotein-1 support the APS-diagnosis in isolated cases. In addition, antibodies against phosphatidylserine can be of value.




The result is given as negative or positive with a value (U/ml)


IgA-autoantibodies against ?2-Glycoprotein-1 are included in the SLICC-criteria for SLE and have been reported in “seronegative” antiphospholipid syndrome (APS), i.e. when the classical antiphospholipid antibodies (lupus anticoagulant, IgG- and/or IgM-antibodies against cardolipin and/or beta2-Glycoprotein-1) cannot be detected.

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20 years experience