Neurofascin-155 (NF155) antibodies - IgG4 subclass determination

Indication

Rapidly progressive Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) that is refractory to standard treatment.

Method

Western Blot

Answer

The result is given as negative or positive.

Interpretation

Neurofascin-155 (NF155) is a paranodal protein of importance for the function of the node of Ranvier. IgG autoantibodies against NF155 have been identified in 5-10% of patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). This subgroup is characterized by younger age at onset (20-30 years), subacute and rapidly progressing course with ataxia, tremor, distal weakness and a poor response to treatment with intravenous immunoglobulin (IVIg) or steroids but may respond to plasmapheresis or rituximab (Querol L et al., 2015). Combination of central demyelination has been reported.

These antibodies are dominated by IgG4 subclass (Vural A et al., 2018).

References

Delmont E et al., Brain 2017: 140; 1851–1858
Vural A et al., Front. Immunol., 14 May 2018

Read more about sampling

Packages and other tests

View other packages CIDP - Chronic Inflammatory Demyelinating Polyneuropathy (537), Inflammatory neuropathy (Guillain-Barré) (534). View other tests Contactin-1 IgG antibodies (CNTN1), Contactin-1 IgG antibodies (CNTN1) – IgG4 subclass determination, Neurofascin-155 IgG and IgM antibodies (NF155)

20 years experience