Neurofascin-155 (NF155) antibodies - IgG4 subclass determination


Rapidly progressive Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) that is refractory to standard treatment.


Western Blot


The result is given as negative or positive.


Neurofascin-155 (NF155) is a paranodal protein of importance for the function of the node of Ranvier. IgG autoantibodies against NF155 have been identified in 5-10% of patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). This subgroup is characterized by younger age at onset (20-30 years), subacute and rapidly progressing course with ataxia, tremor, distal weakness and a poor response to treatment with intravenous immunoglobulin (IVIg) or steroids but may respond to plasmapheresis or rituximab (Querol L et al., 2015). Combination of central demyelination has been reported.

These antibodies are dominated by IgG4 subclass (Vural A et al., 2018).


Delmont E et al., Brain 2017: 140; 1851–1858
Vural A et al., Front. Immunol., 14 May 2018

Read more about sampling

Packages and other tests

View other packages CIDP - Chronic Inflammatory Demyelinating Polyneuropathy (537), Inflammatory neuropathy (Guillain-Barré) (534). View other tests Contactin-1 IgG antibodies (CNTN1), Contactin-1 IgG antibodies (CNTN1) – IgG4 subclass determination, Neurofascin-155 IgG and IgM antibodies (NF155)

Own immunologist