IA-2 antibodies


Suspicion of risk of developing type 1 diabetes (T1D, previously known as insulin-dependent diabetes mellitus, IDDM). The marker may be used for early diagnosis of T1D in both young and old people.


Radioimmunoprecipitation with recombinant antigen. IA-2 is also called ICA512 and is an unusual member of the protein tyrosine phosphatase (PTP) family. As an amino acid has been changed in the catalytic part, it has no enzymatic function. The molecular weight is 106kD.


The result is given as negative or positive with units.


IgG antibodies against IA-2 are frequently found in T1D. About 60-70% of young newly diagnosed people have this antibody. If there are antibodies against islet cells, this confirms the T1D diagnosis. The antibodies can often be observed before clinical signs of T1D. At the time of the diagnosis up to 90% can have antibodies against one or several of the antigens GAD-65, IA-2 or insulin. The percentage of positive patients depends on age (young people have a higher percentage), disease duration (the percentage decreases over time) and ethnic background. Slightly elevated values may occur in autoimmune endocrine diseases, in particular autoimmune thyroiditis.

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