Myasthenia gravis (543)

Tests in package

Acetylcholine receptor antibodies, MuSK antibodies, Striated muscle antibodies, Titin antibodies

Indication

Suspicion of myasthenia gravis or thymoma.

Clinical background

Myasthenia gravis (MG) is an autoimmune neuromuscular disorder that is due to the impulse transmission from the nerve to the muscle is disrupted. MG is characterized by weakness and fatigue in the skeletal muscle. The most common form of MG is seen in approximately 85% of patients and is caused by antibodies to nicotinergic acetylcholine receptors (AChR) on the muscle membrane. The antibodies formed against AChR partially increase receptor metabolism and partially destroy the receptors by means of complement. When the AChR has decreased to about one third on the muscle end plate, patients experience fatigue symptoms.

The second large group of antibodies, antibodies against muscle-specific tyrosine kinase (MuSK), is seen in approximately 40% of patients lacking AChR antibodies. MuSK is a membrane protein in motor end plates and is important for the structure and function of AChR. In a few patients, both forms of antibodies may occur. Recommend analysis procedure is that negative test results for anti-AChR are complemented with anti-MuSK.
Antibodies against titin and striated muscle may sometimes be detected in patients with myasthenia gravis and is associated with an increased incidence of thymoma. An additional marker for strong association with thymoma in Myasthenia Gravis are the ryanodin receptor antibodies.

Serological investigation of Myasthenia gravis:

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Clinical studies

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