Mitochondrial antibodies (AMA)


Suspicion of primary biliary cholangitis (PBC) or autoimmune hepatitis.


Indirect immunofluorescence (IIF)


The result is given as negative, weak, medium or strong positive after evaluation of fluorescence intensity.


Antibodies against mitochondria type M2 is a marker for primary biliary cholangitis (PBC) and occur in about 90% of the patients. Overlap forms between PBC and AIH occur. PBC can also be seen in systemic sclerosis. PBC is a cholestatic disease, i.e. bile ducts are affected by inflammation, which can lead to cholestatic liver values. The antibodies are directed against the pyruvate dehydrogenase complex on the internal membrane of the mitochondrial, so-called M2 antigen.

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20 years experience