Ri (Nova 1/ ANNA-2) antibodies

 

Indication

Suspicion of paraneoplastic syndrome.
 

Method

Immunoblot and indirect immunofluorescence (IIF). For IIF test it is applied a combination of fixed tissues from the nerve, cerebellar, intestinal tissue and pancreas originating from monkeys.

According to guidelines, anti-neuronal antibodies should be detected by at least two independent methods. At Wieslab, IIF and immunoblot are used. According to European guidelines, a positive result should be obtained with both methods to be reliable. According to the supplier the assay sensitivity is 100% and specificity is 100%.

Immunoblot and IIF are accredited analysis for serum samples – read more at the Quality page.
 

Result

Serum: The result is reported as negative, borderline or positive with a titer and blot intensity.

CSF: The result is reported as negative, borderline or positive.

Interpretation

Antibodies against Ri are also called Nova 1 or ANNA-2 (anti-neuron-specific cell nuclear antibodies), and occur less often than antibodies against Hu, but can be seen in paraneoplastic sensory neuronopathy, cerebellar ataxia and/or paraneoplastic encephalomyelitis. Prevalence is strongly associated to small cell lung cancer. Neurological symptoms can precede cancer diagnosis by up to 5 year.

Accredited analysis – read more at the Quality page.

Read more about sampling

References:

PMID: 15342008: 15258215: 21747075: 22448032

Packages and other tests

View other packages Lambert-Eatons myastena syndrom (LEMS) (563), Paraneoplastic Syndromes and Limbic Encephalitis (560, 561 and 562). View other tests AMPA receptor 1 and 2 (GluR1 and GluR2) antibodies, Amphiphysin antibodies, CASPR2 antibodies, CV2/CRMP5 antibodies, DPPX (dipeptidyl aminopeptidase-like protein 6) antibodies, GABA B receptor antibodies, GAD antibodies, Hu antibodies, LGI-1 antibodies, Ma antibodies, NMDA receptor antibodies, Purkinje cell antibodies (Tr, Trotter antigen), Recoverin antibodies, SOX1 antibodies, Titin antibodies, VGKC (voltage gated potassium channel) antibodies, Yo (PCA-1, Purkinje cells antigen 1) antibodies, Zic4 antibodies

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